Liquid chromatography tandem mass spectrometry determination of prohibited diuretics and other acidic drugs in human urine: A Review
Anchal Sharma, Dr. Rajiv Tonk and Dr. Vivek Sharma
This paper reviews liquid chromatographic-mass spectrometric (LC-MS) procedures for the screening, identification and quantification of doping agents in urine and other biological samples and devoted to drug testing in sports. Reviewed methods published approximately within the last five years and cited in the PubMed database have been divided into groups using the same classification of the 2004 World Anti-Doping Agency (WADA) Prohibited List. Together with procedures specifically developed for anti-doping analysis, I.C-MS applications used in other fields (e.g., therapeutic drug monitoring, clinical and forensic toxicology, and detection of drugs illicitly used in livestock production) have been included when considered as potentially extensible to doping control. Information on the reasons or potential abuse by athletes, on the requirements established by WADA for analysis, and on the WADA rules for the interpretation of analytical finding. The basis of human sports doping control is set by the World Anti-Doping Agency (WADA) within the World Anti-Doping Code. It defines doping as mainly the presence of prohibited substances in a specimen; and the use or attempted use of a prohibited substance/method. The list of Prohibited substances covers all classes that are used in doping.
How to cite this article:
Anchal Sharma, Dr. Rajiv Tonk, Dr. Vivek Sharma. Liquid chromatography tandem mass spectrometry determination of prohibited diuretics and other acidic drugs in human urine: A Review. Pharma Innovation 2018;7(7):57-61.