Anti-hyperglycemic activity of methanolic extract of Flacourtia montana in streptozotocin induced diabetic rats
Sindhu K, Sujith S, Shynu M, Suja Rani S, Sanis Juliet and Diwakaran Nair
Diabetes mellitus is a chronic metabolic disorder characterized by hyperglycemia resulting from defects in insulin secretion, insulin action, or both. More than 200 species of plants possess antidiabetic properties which were evaluated mostly by screening tests and some are yet to explore. One such plant named, Flacourtia montana (Family-Flacourtiaceae) was used in these study to evaluate anti-hyperglycemic activity of methanolic leaf extract in STZ induced type I diabetes model. Animals were randomized in to five groups of six each, all the groups except Group I were made diabetic by intraperitoneal injection of Streptozotocin (STZ) at the dose rate of 45 mg/kg body weight. The Group I served as the normal control, Group II and III as STZ and Glibenclamide control. The group – IV and group V were administered methanolic leaf extract @ 100 mg/kg and 250 mg/kg body wt for 15 days. The result revealed an increase in Blood glucose, Triglycerides, Total Cholesterol, LDL-C, AST, ALT level and decrease in HDL-C and non-significant decrease in body weight in all groups except normal control on day zero. The group IV and V exhibited reduced blood glucose level and all other parameters in 15 days of treatment. Thus, the result revealed the anti-hyperglycemic activity of methanolic leaf extract of F. montana. Further analytical experiment is needed to confirm exact mechanism of action.
How to cite this article:
Sindhu K, Sujith S, Shynu M, Suja Rani S, Sanis Juliet, Diwakaran Nair. Anti-hyperglycemic activity of methanolic extract of Flacourtia montana in streptozotocin induced diabetic rats. Pharma Innovation 2018;7(7):22-27.