Vol. 7, Issue 6 (2018)

Author(s):
Devi Violina and Bhupen Kalita

Abstract:
The novel drug delivery approaches towards plant based drugs have been emerging as attractive research field and tremendous success have been achieved in making phytoconstituent more bioavailable and stable. Phytoconstituent of flavonoid class have been known for centuries possessing diverse health giving properties but not extensively formulated to modern dosage forms due the problems related to physicochemical and biopharmaceutic properties. Liposomes are simple microscopic vesicles in which an aqueous volume is entirely enclosed by a membrane composed of a lipid moiety and are well known to alter the bio distribution of entrapped substances by protecting the enclosed materials. They are widely used as vehicles or carriers to target the specific molecule to a specific organ especially in cancer. Due to extensive developments in liposome technology, a number of liposome-based drug formulations are available for human use and many products are under different clinical trials. The present review summarizes the developments in liposomal drug delivery and especially the anti-cancer drugs as liposomes along with the current literature reports on natural flavonoids based anticancer remedies.