Cytotoxicity and anaphylaxis of nab-paclitaxel in female beagle dogs-A case report
B Kala Kumar, B Anilkumar, P Gopal, and G Ambica
A bio equivalent (open labeled, single dose, cross over) study of paclitaxel and Nab-Paclitaxel was conducted in beagle dogs. The dogs were divided into two groups of two each. The first group was administered with paclitaxel in suspension form with 50% ethanol an 50% polyethoxylated castor oil and the second group Nab-Paclitaxel which is a nano particle preparation meant to increase solubility, both were administered by intravenous infusion through the cephalic vein. Nab-paclitaxel administered dogs manifested anaphylactic signs and also cytotoxicity of the gut. Cross reactivity among the taxanes was evident as the dogs injected with paclitaxel were subsequently injected with Nab-paclitaxel, during cross over and such dogs showed severe signs of anaphylaxis. It is reported that hypersensitivity and anaphylaxis are seen even with Nab-paclitaxel although it is more water soluble than paclitaxel.
How to cite this article:
B Kala Kumar, B Anilkumar, P Gopal,, G Ambica. Cytotoxicity and anaphylaxis of nab-paclitaxel in female beagle dogs-A case report. Pharma Innovation 2018;7(6):178-179.