Vol. 7, Issue 6 (2018)

Author(s):
Uzma parveen, Mohd maaz, Umar Jahangir, Roohi azam and Bibhu Prasad panda

Abstract:
Osteoarthritis OA is the most common form of arthritis. Prevalence of osteoarthritis is expected to increase with aging of the population. In OA, the earliest changes in cartilage appear at the joint surface in areas where mechanical forces, in particular shear stress, are greatest particularly in knee joint. Due to its high prevalence, Knee OA generally accounts for disability of lower extremity much more than due to any other disease. It is a major cause of mobility impairment, particularly among females. Knee OA is important not only due to its high prevalence rate compared with other types of OA but also for its appearance at earlier age mainly in younger age groups of obese women. The incidence of knee OA increases by age and additionally increases with longer lifetime and elevated average weight of the population. Current diagnosis for osteoarthritis is based on time consuming and cost-intensive haematological and radiological parameters. There is need to find some alternative to identify the disease at early stage of development and to establish new diagnostic markers for OA. As pyridinoline is much more prevalent in cartilage, assessment of this compound may provide a key for monitoring the increased joint destruction that occurs in arthritic disease at very early stages. In this review we have identified the role of urinary pyridinoline as a promising, time- and cost-effective biomarker of osteoarthritis.