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Vol. 7, Issue 4 (2018)

Influence of asymmetric dimethylarginine, hypoxia of inducible factor 1 alpha and connective tissue growth factor on the course of alcoholic cirrhosis of the liver against the background of exacerbation of chronic bronchitis

Author(s):
NH Virstiuk and ІМ Kobitovych
Abstract:
In patients with alcoholic liver cirrhosis a there was an increase of Asymmetric dimethylarginine, hypoxia induce factor -1α and connective tissue growth factor in the blood, especially in the exacerbation of chronic bronhitis, indicating an increase in endothelial dysfunction, hypoxia and activation of fibro- and angiogenesis in the background of increased inflammation. The positive correlations were detected between Asymmetric dimethylarginine, hypoxia induce factor -1α and the prognostic indeces ADC-MELD, CLIF-CACLF, CLIF-SOFA; they indicate their unfavourable effect on the alcoholic liver cirrhosis course and the threat of acute on chronic liver failure formation.
Pages: 1157-1160  |  568 Views  71 Downloads


The Pharma Innovation Journal
How to cite this article:
NH Virstiuk, ІМ Kobitovych. Influence of asymmetric dimethylarginine, hypoxia of inducible factor 1 alpha and connective tissue growth factor on the course of alcoholic cirrhosis of the liver against the background of exacerbation of chronic bronchitis. Pharma Innovation 2018;7(4):1157-1160.

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