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Vol. 7, Issue 4 (2018)

Comparative in vitro evaluation of some commercial brands of valsartan tablets marketed in Bangladesh

Author(s):
Mehnaz Ali, Fabiha Faizah Ali, Nazma Akhter Rita and Mohiuddin Ahmed Bhuiyan
Abstract:
The availability of numerous brands of valsartan tablets in pharmacies of Bangladesh today places health practitioners in a problem of generic substitution. The aim of the present study was the evaluation and comparison between different brands of valsartan manufactured by various pharmaceutical companies of Bangladesh with different trade names in order to minimize health risk factors and maximize safety of local people. General quality assessments of these tablets like diameter, thickness, hardness, weight variation, friability, disintegration test were also performed according to the established protocols. Dissolution study of the collected commercial samples were performed using a validated UV spectrophotometric method. Active ingredients were also assayed. Dissolution study showed that brand B was the fastest (83.24%) and brand A was the slowest (77.24%) in terms of drug release and assay value of the brands were recorded within 89.1% to 96.3%. This type of study is a good pointer for the evaluation of the idealness of commercial products.
Pages: 1068-1072  |  1401 Views  239 Downloads


The Pharma Innovation Journal
How to cite this article:
Mehnaz Ali, Fabiha Faizah Ali, Nazma Akhter Rita, Mohiuddin Ahmed Bhuiyan. Comparative in vitro evaluation of some commercial brands of valsartan tablets marketed in Bangladesh. Pharma Innovation 2018;7(4):1068-1072.
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