Toll Free Helpline (India): 1800 1234 070

Rest of World: +91-9810852116

NAAS Rating: 5.03, Impact Factor: RJIF 5.98 | Free Publication Certificate
updates
NAAS Rating: 5.03 new
Vol. 7, Issue 4 (2018)

A Review: Pathological studies on imidacloprid toxicity and its amelioration with vitamin C

Author(s):
Komal
Abstract:
Imidacloprid (IMC), the first neonicotinoid insecticide causes almost complete and virtually irreversible blockage of post-synaptic nicotinic acetylcholine receptors (nAChRs) in the central nervous system of insects. The IMC intoxication leads to exhibition of clinical signs such as depression, decreased appetite, excessive salivation, watery diarrhea, muscle weakness and ataxia. IMC causes congestion and hemorrhages in visceral organs such as liver, kidney, lung, spleen, intestine, pancreas and heart. Histopathological lesions due to IMC intoxication are congestion, hemorrhages, necrosis of hepatocytes, fatty change along with lymphocyte infiltration in portal triad area and hyperplasia of bile duct in liver, bronchiolitis, myocarditis, depletion of lymphocytes in lymphoid organs, interstitial nephritis and degeneration of Purkinje cells in cerebellum. Vitamin C acts as a co-factor in various enzymatic reactions and most important free radical scavenger. Vitamin C supplementation resulted in noticeable amelioration of clinical and pathological lesions of the IMC toxicity.
Pages: 999-1002  |  356 Views  6 Downloads
How to cite this article:
Komal. A Review: Pathological studies on imidacloprid toxicity and its amelioration with vitamin C. Pharma Innovation 2018;7(4):999-1002.
The Pharma Innovation Journal