Vol. 7, Issue 4 (2018)
Evaluation of the anti-inflammatory activity of aqueous extracts from Corchorus olitorius (Malvaceae)
TA-BI Irié Honoré, AKE Claude Bernard, Konkon N’Dri Gilles and N'Guessan Koffi
The decoction of Corchorus olitorius leaves is used by ivorian traditional healers for the treatment of inflammation. Regarding the decoction used, this study was carried out to evaluate the anti-inflammatory activity of the acqueous extracts from C. olitorius leaves. These extracts were tested according to the model of acute edema of rat paw induced by carrageenan 1%. The doses of drug orally administered to the animals were as follow: 1470, 2450, 7350 mg / kg. The results obtained with the aqueous extracts of C. olitorius leaves were firstly compared with those of physiological control (NaCl 0.9%) and secondly with those of the reference anti-inflammatory (diclofenac sodium 25 mg / kg). The different comparisons were set up at 1 h, 2 h, 3 h, 4 h, 5 h, 6 h, 12 h and 24 h after the injection of carrageenan to the rats. The parameter considered to appreciate the activity of each treatment was the percentage of increase in leg circumference (% AUG). The results exhibited significant difference (p<0.001) between the % AUG of treatments from extracts of C. olitorius for different doses and those of NaCl. For a dose of 7350 mg / kg administered orally, AUG percentages of plant treatment are statically the same with those of diclofenac 25 mg / kg. This study revealed that the aqueous extracts from C. olitorius leaves have anti-inflammatory properties. It could be considered as a scientific basis for the empirical use of C. olitorius leaves in the treatment of inflammation.
How to cite this article:
TA-BI Irié Honoré, AKE Claude Bernard, Konkon N’Dri Gilles, N'Guessan Koffi. Evaluation of the anti-inflammatory activity of aqueous extracts from Corchorus olitorius (Malvaceae). Pharma Innovation 2018;7(4):800-802.