Vol. 7, Issue 4 (2018)

Author(s):
Muheet, Abha Tikoo, Ifat Ashraf, Shruti Chhibber, JS Soodan, Rajiv Singh, A Muhee, Kaifa Nazim and Adil Majeed

Abstract:
Most of the episodes of diarrhea are self-limiting and should be managed without the indiscriminate use of antibiotics. A variety of anti-secretory agents have been subjected to countless investigations including racecadotril as an adjunct therapy. The present study was conducted to study the efficacy of racecadotril in the management of diarrhea in dogs. A total of eleven dogs suffering from non-hemorrhagic diarrhea were included in the study. Animals were divided into two groups, group I (n=6) was treated with conventional antibiotic therapy and group II with Racecadotril (n=5). The groups were evaluated based on duration of clinical recovery and improvement in the faecal score. The ameliorative action of racecadotril, an enkephalinase inhibitor is attributed to selective anti-secretory activity via protecting endogenous kephalin degradation which induces a selective increase in chloride absorption. The drug holds an effective alternative promise in management of diarrhea without inappropriate antibiotic use.