Toll Free Helpline (India): 1800 1234 070

Rest of World: +91-9810852116

NAAS RATING: 5.23, Impact Factor: RJIF 5.98 | Free Publication Certificate
updates
NAAS Rating: 5.23 new
Vol. 7, Issue 4 (2018)

Effect of piperine solid lipid nanoparticle on haematological alterations in Benzo(A) pyrene induced lung cancer in mice

Author(s):
U Naseema, Ganne Venkata Sudhakar Rao, N Pazhanivel, V Pandiyan and P Sriram
Abstract:
The present study was aimed to evaluate the anticancer potential of piperine solid lipid nanoparticle against benzo(a)pyrene induced lung cancer by analysing the haematological changes in experimental mice. Benzo(a)pyrene was administered orally (50 mg/kg body weight) to induce lung cancer in Swiss albino mice. The levels of haemoglobin (Hb), packed cell volume (PCV), total erythrocyte count (TEC), lymphocytes and platelets (PLT) were lower while the levels of total leukocyte count (TLC) and neutrophils were higher in the mice administered with benzo(a)pyrene alone and in combination with piperine. Post-treatment with piperine solid lipid nanoparticles (100mg/kg body weight) significantly reversed all these changes. The results of this study indicated the potential benefits of piperine and its nanoparticle in cancer treatment in Swiss albino mice.
Pages: 366-368  |  394 Views  9 Downloads
How to cite this article:
U Naseema, Ganne Venkata Sudhakar Rao, N Pazhanivel, V Pandiyan, P Sriram. Effect of piperine solid lipid nanoparticle on haematological alterations in Benzo(A) pyrene induced lung cancer in mice. Pharma Innovation 2018;7(4):366-368.
The Pharma Innovation Journal