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Vol. 7, Issue 4 (2018)

Effect of feeding normal and high cholesterol diet incorporated with encapsulated and non-encapsulated Bifidobacterium bifidum 235 and prebiotics on serum triglycerides of S.D. Rats

Author(s):
Karthik Kotha, Kotinagu Korrapati and Kondal Reddy
Abstract:
In the present experiment, effect of encapsulated and non encapsulated synbiotic (prebiotic and probiotic) on the feed intake, body weight gain, and feed conversion ratio and serum lipid profile is studied. The probiotic bacteria used in the study is Bifidobacterium bifidum 235. The feeding experiment was conducted in S.D. rats which were fed with high cholesterol diet (group I), normal diet (group II), high cholesterol diet with encapsulated Bifidobacterium bifidum 235 (group III), high cholesterol diet with non encapsulated Bifidobacterium bifidum 235 (group IV), high cholesterol diet with encapsulated synbiotic (group V), and high cholesterol diet with non encapsulated synbiotic (group VI). The effect of supplementation of encapsulated Bifidobacterium bifidum 235 with prebiotics in milk fat rich high cholesterol diet on serum profile of experimental rats was studied for 45 days. The serum samples for estimation of triglycerides were analyzed at 15 days interval. The triglycerides (10.49%) of rats feed on high cholesterol diet supplemented with encapsulated synbiotic were significantly lower than all the other groups. There was further reduction in triglycerides (10.14%) has observed in rats fed with high cholesterol diet supplemented with encapsulated Bifidobacterium bifidum 235 which may be due to encapsulation has protected organisms from adverse conditions of gastro intestinal tract, relatively lesser in triglycerides (7.89%) was seen rats fed with high cholesterol diet with non encapsulated synbiotic may be due to feeding of non encapsulated synbiotic. In rats fed with high cholesterol diet with non encapsulated Bifidobacterium bifidum 235 there was least reduction in triglycerides (7.97%) when compared to the group fed only on control diet.
Pages: 356-359  |  353 Views  2 Downloads
How to cite this article:
Karthik Kotha, Kotinagu Korrapati, Kondal Reddy. Effect of feeding normal and high cholesterol diet incorporated with encapsulated and non-encapsulated Bifidobacterium bifidum 235 and prebiotics on serum triglycerides of S.D. Rats. Pharma Innovation 2018;7(4):356-359.
The Pharma Innovation Journal