RNA interference: A review
Athe Rajendra Prasad, N Govardhana Sagar, V Bhavana, V Tejaswini, Amit Baranwal and Satish Kumar
RNA interference (RNAi), as commonly defined, is a phenomenon leading to post-transcriptional gene silencing (PTGS) after endogenous production or artificial introduction into a cell of small interfering double strand RNA (siRNA or miRNA) with sequences complementary to the targeted gene (Bosher and Labouesse, 2000). Whereas the transcription of the gene is normal, the translation of the protein is prevented by selective degradation of its encoded mRNA. However, PTGS is not restricted to RNAi and has emerged as a more complex mechanism that involves several different proteins and small RNAs.
How to cite this article:
Athe Rajendra Prasad, N Govardhana Sagar, V Bhavana, V Tejaswini, Amit Baranwal, Satish Kumar. RNA interference: A review. Pharma Innovation 2018;7(4):37-41.