Vol. 7, Issue 3 (2018)

Author(s):
Pravas Ranjan Sahoo, Tapas Kumar Patabandha, Anjan Kumar Sahoo, Swagat Mohapatra and Prakash Chanda Behera

Abstract:
p53, an important tumor suppressor gene that not only regulates the cell cycle but also helps in apoptosis, genomic stability, and inhibition of angiogenesis which leads a better platform for invention of new therapeutics and diagnostics in human as well as in animals by exploiting this gene. So phylogenetic analysis of this gene is essential to know the evolutionary relationship among the animals for better understanding in modern biological research. In this study, the p53 tumor suppressor mRNA gene of bos Taurus was retrieved and percentage identity and similarity was estimated with other selected animals through basic alignment search tool (BLAST). Multiple sequence alignment and phylogenetic analysis of this gene was performed through in sillico platform. In this study, the identity and similarity percentage was found more than 70% in all selected animals which inferred that this gene is conserved among all mammalian species. So this study would be helpful for the better development of research strategies about of p53 gene for the animal as well as human benefit in nearest future.