Vol. 7, Issue 3 (2018)

Author(s):
K Shalini, NA Aleykutty and Jyoti Harindran

Abstract:
Inflammation is the beneficial host response to challenges by foreign bodies or to tissue injury. There is an ongoing research to develop safer and more effective drugs for the therapy of inflammation and psoriasis. Psoriasis can be considered as a T-cell mediated disease, with a complex role for a variety of cytokines interaction between keratinocytes and T- lymphocytes. Epidermal hyper proliferation, abnormal keratinocyte differentiation, angiogenesis and blood vessel dilatation can be observed in this disease condition. Strobilianthes ciliatus of Acanthaceae family is highly potential medicinal plant in Ayurveda in the treatment of inflammation and skin diseases. Petroleum ether and ethanolic extract of leaf and ethanolic extract of stem of Strobilianthes ciliatus were screened for anti-psoriatic and anti-inflammatory activities by in-vitro models. Psoriatic activity was studied by MTT assay on HACAT cell lines. Cyclooxygenase inhibition of the extracts were analyzed using RAW 264.7 cell lines. Petroleum ether extract of leaf showed high anti-psoriatic activity and cyclooxygenase inhibition than the other extracts. Significant activity shown by the extract suggests bioactivity guided isolation to identify the promising constituent present in the extract.