Vol. 7, Issue 12 (2018)

Author(s):
Akansha Mishra and Saurabh Mishra

Abstract:
The G.I.T. transit time of a dosage form needs to be controlled in order to get maximum benefit of therapeutic agent contained in it and to develop sustained release formulation. Floating microspheres are one of the tried method which increase the stay time of the drug in stomach by virtue of low density, the buoyancy of microspheres is increased which make them floating in gastric fluid. Floating microspheres are gaining special attention because they remain buoyant and distribute drug uniformly in stomach, increase bioavailability of drug that are unstable at intestinal pH. The concept of this dosage form has also been utilized to reduce irritant effect of drug in stomach as the direct contact with gastric mucosa is reduced. Gastro retentive floating microspores provide continuous release of drug from a dosage form, with variation in ingredients added they can achieve various release patterns. The present review brings together the essentials of floating microspheres to form gastro retentive drug delivery system. It concisely gives information on physiology of gastric emptying system in correlation to floating drug delivery system.