Vol. 7, Issue 12 (2018)

Author(s):
Rama Rao Nadendla and KNV Chenchu Lakshmi

Abstract:
Novel 5-aryl -7-[(1E)-aryl substituted]-1H, 3H-pyrido [2, 3-d] pyrimidine-2, 4-dione derivatives (1p-15p) were synthesized in two steps .step 1 by reacting various aromatic aldehydes with aliphatic ketone i.e acetone under strong basic conditions by conventional method to form1, 5-diaryl substituted-(E, E)-1, 4-pentadien-3-one derivatives which were condensed with 6-amino uracil to form 5-Aryl -7-[(1e)-Aryl Substituted]-1H, 3H-Pyrido [2, 3-D] Pyrimidine-2, 4-Dione Derivatives . The purity and progress of reaction was assessed by TLC and melting point. Synthesised compounds were characterised by various spectroscopic methods such as IR, H1 &C13 NMR. The synthesised pyridopyrimidine were evaluated for their In vitro antioxidant and anti-inflammatory activities by DPPH assay and heat haemolysis method respectively. The results indicate that pyridopyrimidine showed dose dependent free radical scavenging activity in DPPH method and in RBC stabilisation method. 12p and 13p compounds showed higher free radical scavenging inhibition and compounds 1p, 9p, 10p, 11p, 12p and 14p exbhited good stabilisation of RBC membrane nearer to standard drug. The study provides a good scope for further development of novel targeted molecules.