Vol. 7, Issue 12 (2018)

Author(s):
Deepak Devidas Sonawane, Rakesh Kumar Jat and Ashish Yashwantrao Pawar

Abstract:
The solubility and bioavailability of BCS Class II drugs can be improved by developing a method reducing the particle size and converting the drug into amorphous state. The Nanocomposites (NCs) of poorly soluble drugs using natural and synthetic carriers can be a promising approach for oral delivery of low solubility drug. In the present study nanocomposites were formulated using microwave induced diffusion technique (MIND) for solubility enhancement of poorly water soluble (BCS class II) model drug Miconazole Nitrate. Its oral bioavailability is very low due to low aqueous solubility. The nanocomposites of Miconazole Nitrate were developed using natural and synthetic carriers such acacia, Chitosan, HPMC K4M and Avicel 101. Different Physical mixture & nanocomposites formulations were prepared with varying ratios of drug and carriers. The selections of natural & synthetic carriers were based on their surfactant and wetting properties. In case of developed nanocomposites, the optimum drug-to-carrier ratio was found to be 1:4 with Chitosan as a carrier which enhanced solubility nearly 16 fold as compared to pure drug. From the dissolution study of the nanocomposites there was evidently a remarkable improvement of the dissolution rates in NCs compared with the pure Miconazole nitrate (In vitro drug release of 88.43% as compared to 44.31%. of pure drug). The optimized nanocomposites were characterized by Fourier transform infrared spectroscopy, Differential scanning calorimetry, X-ray diffraction and Scanning electron microscopy. From Solubility, In vitro drug release and Physical characterization of carriers it is clear that the nanocomposites MCN4 formulation was found to be optimum in terms of solubility enhancement of a drug by microwave assisted synthesis. The MIND technique employed in this study is green, cost-effective and a promising approach for solubility enhancement.