Vol. 7, Issue 12 (2018)

Author(s):
Deepa Rajendiran, Sangeetha Raghavan, Selvakumar Kandaswamy and Krishnamoorthy Gunasekaran

Abstract:
Mimosa pudica Linn is a traditional plant with high medicinal value used for the treatment of numerous diseases. The parts of the plant such as leaves, roots and whole plant used for the treatment of diabetes mellitus. The hepatoprotective activity of ethanol extract of Mimosa pudica leaves extract was studied in high fat diet (HFD) and streptozotocin (STZ)-induced type 2 diabetes mellitus. The rats were divided into five groups of six animals each. Type 2 diabetes mellitus was induced by feeding high fat diet for two weeks followed by intraperitoneal injection of streptozotocin (35 mg/kg bwt). The diabetic rats were administered Mimosa pudica leaves extract (300mg/kg bwt) daily for 30 days. The results showed the significant increase of glucose, AST, ALT, ALP and LDH whereas the insulin and total protein level were decreased in STZ induced diabetic rats. The treatment of Mimosa pudica leaves extract showed hepatoprotective activity by significantly restored the activity of liver markers.