Vol. 7, Issue 12 (2018)
Elucidation of possible antibacterial effects of statins against primary pathogens of mastitis in cows
Vadivoo VS, Dhinakar Raj G, Balasubramanian S, Suresh Subramanion B and Kumanan K
Statins act as selective and competitive inhibitors of HMG-CoA reductase thus inhibiting the synthesis of cholesterol in the liver. In addition to this activity, the other pleiotropic effects of statins are anti-inflammatory, immunomodulatory, antioxidant, antimicrobial activity and anticoagulant activities. The aim of our study was to assess the effect of statins on the bovine mastitis causing pathogens. Simvastatin one of the classes of statins was used in this study to elucidate its antimicrobial property against Staphylococcus aureus isolated from bovine mastitis milk. Simvastatin at the minimum concentration of 31.25 µg/ml produced a maximum percent reduction in the growth of the S. aureus based on the cfu/ml. The maximum inhibitory effect of the Simvastatin was noticed at 4 hours. Simvastatin produced inhibition of all the four S. aureus isolates from mastitis milk. Based on this pilot in vitro study, Simvastatin at concentration of 31.25 µg /ml had an antibacterial effect on the Staphylococcal isolates from mastitis milk.
How to cite this article:
Vadivoo VS, Dhinakar Raj G, Balasubramanian S, Suresh Subramanion B, Kumanan K. Elucidation of possible antibacterial effects of statins against primary pathogens of mastitis in cows. Pharma Innovation 2018;7(12):30-33.