Vol. 7, Issue 11 (2018)

Author(s):
Deepika Yadav, Shiv K Yadav, Gaurav Jain, Avijit Mazumder and Roop K Khar

Abstract:
Clove is commonly used in Ayurveda, which is traditional system of Indian medicine. Clove is the prominent source of eugenol. Eugenol is reported for various pharmacological activities like anaesthetic activity, antioxidant potential, antimicrobial activity, anti-inflammatory activity, anti-cancer effects, neuroprotective action, hypolipidemic efficiency and anti-diabetic action. Therefore, in current study we investigated the effect of eugenol against the increased current electroshock model of epilepsy. Eugenol at dose levels of 0.20 ml/kg and 0.40 ml/kg, i.p. increased the threshold current significantly. The results demonstrate that Eugenol can be used for the treatment of generalized type seizures.