Vol. 7, Issue 11 (2018)

Author(s):
Shiji Sheeja Saju, Bhuvana Plakkot and Babitha Vazhoor

Abstract:
Follicular blood vessel network status is an essential criterion in determining the selection of dominant follicle/s. Angiogenesis is a process of vascular growth which is vital for follicular development and ovulation. The development, proliferation, and growth of these capillaries are controlled by angiogenic factors produced by granulosa and theca cells. Gonadotropins (FSH and LH) function as the primary survival factors for ovarian follicles and the anti-apoptotic effects are probably mediated by the ovarian growth factors. Of these growth factors Angiopoietin (ANPT)-Tie signaling pathways have pivotal roles in regulating angiogenesis. A balanced action of Angiopoietins-Tie pathway along with vascular endothelial growth factor plays a vital role in vascular stabilization thus ensuring the preferential delivery of nutrients and gonadotropins to dominant follicles, compared with the subordinated follicles. Thus Angiopoietin-Tie pathway is vital for the remodeling and maturation of the developing vasculature, which helps in the formation of dominant follicle/s.