Histopathological changes induced by Malathion in wistar rats and its reversal by Emblica officinalis
Sharma S, Kaushik D and Sharma RK
Malathion, an organophosphate insecticide has been used in agriculture and domestic practices since mid-1940s. Present study aimed to analyze the preventive effect of Emblica officinalis juice against Malathion induced toxicity in histological structures of liver of male wistar rats. Mature Wistar rats were divided into 7 groups fed orally with different formulations of Malathion and Emblica officinalis juice (equivalent to 5 mg/kg dose of vitamin C) for the duration of 10 days. Group A serves as control. Group B and C administered with 100 mg/kg and 500 mg/kg of Malathion respectively. Recovery groups (Group D supplemented with 100 mg/kg of malathion along with Emblica officinalis juice (EOJ); Group E tested with 500 mg/kg of malathion along with EOJ; Group F administered with for 5 days and then supplemented with EOJ till 10th day; Group G treated with 500 mg/kg of malathion for 5 days and then supplemented with EOJ till 10th day). Present study revealed Malathion induced groups showed Sign of pyknosis in Hepatocytes, alteration in normal morphology of liver, depletion in organelles, congestion of blood vessels with hemorrhage, increased vacuolization in cytoplasm of hepatocytes in dose dependent manner. EOJ supplemented groups showed normal cellular arrangement, reduced signs of necrosis, significant decrease in number of vacuoles and intracellular spaces, elevated level of hepatocytes. Present study concluded that Malathion induced devastating effects on liver morphology and Emblica officinalis juice reverse the deleterious effects of Malathion.
How to cite this article:
Sharma S, Kaushik D, Sharma RK. Histopathological changes induced by Malathion in wistar rats and its reversal by <em>Emblica officinalis</em>. Pharma Innovation 2018;7(11):500-503.