Anti-biofilm potential of aqueous Eucalyptus leaf extract against nosocomial pathogens: Staphylococcus and Pseudomonas aeruginosa
Dr. Sandeep Kaur, Nitika Sharma, Aanchal, Aditi Ghambir, Aditi Sharma, Akshima Sharma and Dr. Vandana Sharma
Biofilm infections pose a major challenge for the physicians and researchers worldwide due to their inherent recalcitrance towards antibiotic treatment and numerous survival and immune evading strategies.The present study focuses on exploring alternative safe solutions to cater to the biofilm bacteria. It evaluated the anti- biofilm potential of aqueous leaf extract obtained from Eucalyptus against two clinically significant bacteria (S. aureus and P. aeruginosa) forming potent biofilms. Also, these bacteria have been shown to be highly resistant to the action of antibiotics making the situation worse. In vitro biofilms were established for both the strains on microtiter plate surface and on Foley catheter surface. The treatment was done with Eucalyptus leaf extract (1:1) and the biofilm progression was monitored. Results indicates significant decline in the adhered viable load in both the treated bacterial species. Eucalyptus aqueous extract from leaves represented a potential alternative with significant anti-biofilm ability against S. aureus and P. aeruginosa. This calls for further exploring the potential of Eucalyptus extract in combination with antibiotic as combination systems for possible synergism against resistant clinical isolates.
How to cite this article:
Dr. Sandeep Kaur, Nitika Sharma, Aanchal, Aditi Ghambir, Aditi Sharma, Akshima Sharma, Dr. Vandana Sharma. Anti-biofilm potential of aqueous <em>Eucalyptus</em> leaf extract against nosocomial pathogens: <em>Staphylococcus</em> and <em>Pseudomonas aeruginosa</em>. Pharma Innovation 2018;7(11):425-432.