Nano-selenium activates Mucin gene expression in intestinal crypt cells
A Mangala Gowri, A Abiroopa, AS Vaishnavi and S Nandhini
Selenium is known for its antioxidant activity and it reduces the effects of free radicals in cells. The role of selenium is an essential nutrient to prevent oxidative damage in cells. However the limitation on its wide application is due to the narrow range in between the nutritional and tolerable intake levels. The optimization between supplemental Se acquired through diet and its bioavailability depends mainly on the source of selenium which requires proper models to mimic in vivo understanding of food and drug molecules during absorption to excretion which is lacking in the present scenario. But recent knowledge on crypt cell culture approaches are promising in the designing of suitable models to explore in vivo drug and cellular interactions. In the present study to mimic intestinal effects, the primary cultured intestinal crypt cells, representing true stem cell compartment were applied to analyse the effect of selenium nano particle intake with reference to expression of Mucin gene which has active role in the nutrient digestion and absorption.
How to cite this article:
A Mangala Gowri, A Abiroopa, AS Vaishnavi, S Nandhini. Nano-selenium activates Mucin gene expression in intestinal crypt cells. Pharma Innovation 2018;7(11):421-424.