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Vol. 7, Issue 11 (2018)

Fluoroquinolones: An old drug with new dimensions

Dr. Arpita Shrivastav and Dr. Neeraj Shrivastav
The fluoroquinolones are a chain of synthetic antibacterial agents preferably used in the treatment of a variety of bacterial infections. These agents act through inhibition of the DNA gyrase, an important enzyme responsible for DNA replication by affecting DNA-rejoining reaction. The inhibition of the resealing leads to the liberation of fragments that are subsequently destroyed by the bacterial exonucleases. All fluoroquinolones accumulate within bacteria very rapidly, so that a steady-state intra bacterial concentration is obtained within a few minutes. Resistance develops slowly and is usually chromosomal and not plasmid mediated. However, development of resistance and transfer between animal and human pathogens has become a fervently argued issue among the microbiologists. Another concern regarding the use of new quinolones in the veterinary field is a possible detrimental effect on the environment. It still seems unlikely that the controlled use of veterinary quinolones will give rise to unfavorable effects on the environment.
Pages: 413-417  |  578 Views  182 Downloads

The Pharma Innovation Journal
How to cite this article:
Dr. Arpita Shrivastav, Dr. Neeraj Shrivastav. Fluoroquinolones: An old drug with new dimensions. Pharma Innovation 2018;7(11):413-417.

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