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Vol. 7, Issue 11 (2018)

Haemato-biochemical alterations and stress response to pre-emptive administration of meloxicam, ketoprofen, tolfenamic acid and flunixin in dogs

Author(s):
S Dharmaceelan, R Manikandan, K Jayakumar, S Senthilkumar and P Selvaraj
Abstract:
A clinical research was conducted in 24 dogs which were randomly divided into four groups viz., group I, II, III and IV to evaluate the haemato-biochemical changes and stress response by addition of preemptive meloxicam (0.2mg/kg), ketoprofen (2.0mg/kg), tolfenamic acid (4.0mg/kg) and flunixin (1.0mg/kg) in the anaesthetic protocol following Ovariohysterectomy (OHE) in dogs. After 15 minutes, midazolam was administered at the dose rate of 0.3mg per kg to all the animals. General anaesthesia was induced with propofol at the dose rate of 6 mg/kg in all the animals and maintained with isoflurane. Haemoglobin (Hb) in g per dL, packed cell volume (PCV) in per cent (%), total erythrocyte count (TEC) in millions per microliter (106 /µL), total leucocyte count in thousands per microliter (103 /µL), platelet count in Lakhs per microliter (105/µL), Serum urea nitrogen (mg/dL), serum creatinine (mg/dL), and serum cortisol (ng/ml) were measured before premedication, immediately, 3 h and 12 h after surgery in all animals. The results revealed a significant (p<0.05) reduction in Hb, PCV and TEC immediately after surgery and 3 h of surgery in all the groups. There was no significant difference in platelet count between different time intervals, but difference was noticed among the groups. Biochemical parameters studied were within physiological range but showed a significant increase (p<0.05) immediately after surgery and at 3 h of surgery. The cortisol level increased immediately after surgery and at 3 h of surgery in all the animals.
Pages: 218-221  |  708 Views  47 Downloads


The Pharma Innovation Journal
How to cite this article:
S Dharmaceelan, R Manikandan, K Jayakumar, S Senthilkumar, P Selvaraj. Haemato-biochemical alterations and stress response to pre-emptive administration of meloxicam, ketoprofen, tolfenamic acid and flunixin in dogs. Pharma Innovation 2018;7(11):218-221.
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