Vol. 7, Issue 11 (2018)

Introduction: Paracetamol, a widely used analgesic and antipyretic agent, suffers from limitations in conventional oral formulations, including limited bioavailability and rapid clearance. Cubosomal formulations, characterized by their nanostructured lipid carriers, offer promising advantages for drug delivery due to their stability, high drug loading capacity, and controlled release properties.

Methodology: Cubosomal formulations of paracetamol were prepared using a hot homogenization technique, incorporating monoolein, phytantriol, and Poloxamer 407 as the lipid matrix and stabilizer. Characterization involved assessing particle size, zeta potential, encapsulation efficiency, and drug loading using dynamic light scattering and high-performance liquid chromatography. In vitro release studies were conducted in phosphate-buffered saline, while In vivo bioavailability and safety assessments were performed in rats.

Analysis: The cubosomal formulations exhibited optimal physicochemical properties, including uniform particle size, negative zeta potential, high encapsulation efficiency, and controlled release of paracetamol. In vivo studies demonstrated enhanced bioavailability and therapeutic efficacy of the cubosomal formulation compared to traditional tablet formulations, with no significant adverse effects observed.

Discussion: The results highlight the potential of cubosomal formulations to address the limitations of conventional paracetamol delivery methods. The controlled release profile, enhanced bioavailability, and safety profile of the cubosomal formulation suggest its suitability for improved pain and fever management.

Conclusion: In conclusion, this study demonstrates the feasibility and efficacy of cubosomal formulations in optimizing paracetamol delivery. Future research directions may focus on expanding the applicability of cubosomes to other drugs and exploring targeted delivery strategies, ultimately advancing the field of nanomedicine and improving patient care.