To compare the analgesic effect of thiocolchicoside and ketoprofen alone and their combination in male albino wistar rats by using digital analgesiometer for the degree of analgesia and the time course of action.
Materials and Methods:
Analgesia was studied in male albino wistar rats using the radiant heat method. For each test, four groups of six animals each were orally fed with a single dose of thiocolchicoside, ketoprofen, and combination of thiocolchicoside and ketoprofen and normal saline as control, respectively.
Results: In all three drug treatments showed significant analgesia (P < 0.001) as compared to control, but there was significant difference in the analgesia produced by drugs in combination. The radiant heat method demonstrated a quicker onset of action with thiocolchicoside and ketoprofen, whereas greater degree of analgesia was seen with the combination of thiocolchicoside and ketoprofen than the individual drug, though this difference was statistically significant.
Conclusions: Thiocolchicoside and ketoprofen combination offers advantage over thiocolchicoside and ketoprofen alone, in terms of degree of analgesia or onset of action. Therefore, our study supports the reports claiming the efficacy of the fixed dose combination of thiocolchicoside and ketoprofen greater than individual drug alone.