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Vol. 7, Issue 10 (2018)

Design, synthesis and characterization of novel thieno [2, 3-d] pyrimidines for anti-bacterial and anti-fungal screening

Author(s):
L Srikanth Reddy and B Eswar Naik
Abstract:
A series of novel 4-Substituted & different Substituted Heterocyclic- N-(2-thiomorpholin othieno [2, 3-d] pyrimidin-4-yl) benzamide derivatives were synthesized by a facile Five-step procedure that afforded advantages of mild reaction conditions, simple protocol and good yields. The structures of the final compounds were confirmed by IR, NMR, EI-MS. The final compounds were screened for their anti-bacterial activity against Staphylococcus aureus (S. aureus) and Bacillus subtilis (B. subtilis)from Gram positive group of bacteria and Pseudomonas aeruginosa (P. aeruginosa) and Escherichia coli (E. coli)from Gram negative group of bacteria and antifungal activity against Aspergillus niger (A. niger) and Candida albicans (C. albicans). Anti-bacterial and anti-fungal activities were Evaluated and compared with the standard drugs Such as Amoxicillin & Flucanazole From anti-bacterial and anti-fungal activity screening results, it has been observed that compounds 8j, 8i, 8f and 8e possess good activity.
Pages: 456-465  |  220 Views  13 Downloads
How to cite this article:
L Srikanth Reddy, B Eswar Naik. Design, synthesis and characterization of novel thieno [2, 3-d] pyrimidines for anti-bacterial and anti-fungal screening. Pharma Innovation 2018;7(10):456-465.
The Pharma Innovation Journal