To compare the analgesic activity of thiocolchicoside and ketoprofen alone and their combination with piroxicam in male albino wistar rats by using digital analgesiometer for the degree of analgesia and the time course of action.
Materials and Methods: Analgesia was studied in albino rats using the radiant heat method. For each test, five groups of six animals each were orally fed with a single dose of test drugs thiocolchicoside, ketoprofen, and combination of thiocolchicoside and ketoprofen, piroxicam as standard and normal saline as control, respectively.
Results: In all four drug treatments showed significant analgesia (P<0.001) as compared to control, but there was significant difference in the analgesia produced by drugs in combination. The radiant heat method demonstrated a quicker onset of action with thiocolchicoside and ketoprofen, whereas greater degree of analgesia was seen with the combination of both drugs than that of individual drugs and more effective than the piroxicam, though this difference was statistically significant.
Conclusions: thiocolchicoside and ketoprofen combination offers advantage over thiocolchicoside and ketoprofen alone and greater efficacy than piroxicam, in terms of degree of analgesia or onset of action. Therefore, our study supports the reports claiming the analgesic efficacy of the fixed dose combination of thiocolchicoside and ketoprofen greater than the individual drugs alone and piroxicam.