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Vol. 7, Issue 10 (2018)

Synthesis, characterisation, physiochemical properties and biological evaluation of some novel 2-(3-oxo-dihydro-2h-indol-2-ylidene) hydrazinecarboxmide Schiff bases

Author(s):
Maddumala Sowjanya, Baratam Anupama, R Satyavani, M Manoj Kumar and KNV Chenchu Lakshmi
Abstract:
Novel 2-(2-oxo-dihydro-2H-indol-2-ylidene) hydrazine carboxmide Schiff bases (1s-14s) were synthesized by reacting various aliphatic and aromatic (substituted & unsubstituted) amines with isatin -3-semicarbazone under strong basic conditions by conventional method. The purity and progress of reaction was assessed by TLC and melting point. Synthesised compounds were characterised by various spectroscopic methods such as IR, H1 &C13 NMR. Physical parameters such as isoelectric point, logP and logD, pka, solubility (Log S and mg/ml) were determined by Chem Axon Chemicalize instant Cheminformatics solution software. The synthesised Schiff bases were evaluated for their antibacterial(two gram-positive bacteria Staphylococcus aureus ATCC 6538 and Bacillus subtilis ATCC 6633 and two Gram-negative bacteria Escherichia coli ATCC 8739 and Pseudomonas aeruginosa ATCC 9027), antifungal (Aspergilus Niger MTCC 282 and Pencillium notatum NCIM 742,) and antioxidant activities(DPPH Free radical scavenging assay). The results of Chem Axon revealed that compounds had very low solubility in polar solvents, isoelectric point (6.5-8.5), log p (0-3.5), acidic pKa (8-9) basic pKa (5-8).Antimicrobial studies revealed that compounds 3s, 5s, 7s and 12s possess good antibacterial and antifungal properties. Compounds 5s, 7s, 8s, 11s, 12s exhibited better free radical scavenging assayof all the compounds, 12s found to possess good antimicrobial and antioxidant activities. The study provides a good scope for further development of novel targeted molecules.
Pages: 341-351  |  234 Views  12 Downloads
How to cite this article:
Maddumala Sowjanya, Baratam Anupama, R Satyavani, M Manoj Kumar, KNV Chenchu Lakshmi. Synthesis, characterisation, physiochemical properties and biological evaluation of some novel 2-(3-oxo-dihydro-2h-indol-2-ylidene) hydrazinecarboxmide Schiff bases. Pharma Innovation 2018;7(10):341-351.
The Pharma Innovation Journal