Vol. 7, Issue 10 (2018)

Objectives: The aim of the study is to show the effect of migraine prophylaxis on Psychiatric changes and Quality of sleep. Besides, the objective of our study is to determine frequency, severity and duration of migraine, severity of depression and anxiety and their minimization.

Methods: About 150 patients above 10 years where included in the study. The required data was collected from the patients through direct interview using standard questionnaires. The acquired data was evaluated based on the standard questionnaire scales i.e. Migraine Disability Assessment Scale, Zung Self Rating Depression scale, Zung Self-Rating Anxiety scale and Pittsburgh Sleep Quality Index were used to diagnose the severity of migraine, anxiety and depression along with impaired quality of sleep in migraine patients.

Results: We found a higher significant prevalence and risk of incident migraine is in females than in males. Age groups of 25-45 years are at a higher risk of migraine incidence. Prevalence of mild to severe depression (according to Zung Self-Rating Depression Scale) 29.3% and moderate to severe anxiety (according to Zung Self-Rating Anxiety Scale) is 27.3%. The study shows prevalence of migraine without aura (83%) is higher than migraine with aura (6%). In our study Propranolol (46.67%), Topiramate (39%), Amitriptyline (32%) were the most prescribed drugs. All the three drugs has shown an effect on frequency, severity, duration of headache with the significance of P<0.01 similarly these drugs has shown a significant difference in scores of migraine disability assessment index, Zung self rating depression scale, Zung self-rating anxiety scale and Pittsburgh sleep quality index (P<0.01).

Conclusion: Propranolol was the most prescribed drug among all the prophylactic drugs prescribed. Out of all the prophylactic drugs propranolol, amitriptyline, topiramate when used individually or in combination form it was observed that there is decrease in factors such as migraine frequency, severity, duration, MIDAS scores, depression and anxiety, whereas quality of sleep improved. In our study we also observed that not only amitriptyline (anti-depressant) but also propranolol and topiramate showed effect on Psychiatric symptoms and quality of sleep.