The aim of the study is early possible detection of any abnormal biochemical parameter will help in diagnosis of renal diseases which could be helpful in prevention of complications and permanent damage of kidney. The aim of the present study is taken up to assess the severity of the renal damage in diabetic and hypertensive subjects using biochemical parameters such as Creatinine, Total protein and Albumin in Serum and urine which are also estimated by standard procedures.
Method: The present study is carried out in Department of Biochemistry, SIMS. The relevant data is gathered from the Department of medicine, SIMS and hospital during the year 2016. In the present study, there are 4-groups namely control (Normal subjects), Diabetic Group, Hypertensive Group, Diabetic and Hypertensive Group. 20 patients in each group and age varies between 42 to 65 years in all the subjects of all groups. All the cases were selected based on the disease. The study was done in patients who are admitted in Department of medicine.There is an increase in Urinary total protein, Urinary Albumin
Results: There is an increase in Urinary total protein, Urinary Albumin and Serum Creatinine. All the patients of three diseased groups showed increased levels of Urinary Total Protein and Albumin. Showing much significance statistically when compared with when normal group. P-Values for all the urinary parameters are highly significant as they are less than 0.05. P-value is significant for serum creatinine and serum albumin in diabetic and Hypertensive group. The results indicate the extent of damage of the glomerular membrane. Due to damage of glomerular membrane, loss of total protein and albumin is higher in diabetic and hypertensive group compare to normal P Values of diabetes with hypertension are more significant than only diabetes or hypertension.
Conclusion: The results concluded that, estimation of Urinary creatinine, total protein and albumin in 24-hours urine gives valuable information in early diagnosis can lead to prognostic assessment and suitable treatment as early as possible which can prevent further damage to gloumerular Membrane in particular and other systems of diabetic and hypertensive patient.