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Vol. 7, Issue 1 (2018)

Left ventricular 2D speckle tracking echocardiography, quality of life and annual mortality in patients with dilated cardiomyopathy from cardiac transplant waiting list

Author(s):
Artur Gabriyelyan
Abstract:
For patients with dilated cardiomyopathy drug therapy is often ineffective and heart transplantation remains the single radical but the most efficient method of treatment. At the same time, investigators suggest that the stem cell transplantation (SCT) can be a promising palliative concept for this group of the patients.
The aim of research was to study the data of left ventricular 2d speckle tracking echocardiography, quality of life and annual mortality in patients with dilated cardiomyopathy in pharmacological treatment versus stem cell transplantation.
A total 40 people were involved in the study - group 1 - conservative treatment (20 patients); group 2 (20 patients), where transplantation of cord stem cells was used. At the beginning of the study, clinical data and physical investigation were analyzed. Examinations included ECG, cardiac ultrasound techniques, strain rate imaging and N-terminal pro brain natriuretic peptidе was provided.
It was proved, that in patients from cardiac transplant waiting list with dilated cardiomyopathy stem cell therapy promotes a significant increase of left ventricular ejection fraction, parameters of systolic (S, ν, p<0,05) and diastolic (e, a, p<0,05), longitudinal (p<0,05), transmural (p<0,05) and circular (p<0,05) strain rate imaging versus conservative therapy. It was set improvement both physical (p<0,05) and mental (p<0,05) health by Minnesota survey in the group of DCM from cardiac transplant waiting list, where transplantation of umbilical cord blood stem cells was used in compare to conservative treatment. Cardiovascular and total mortality relative risk became 15,0% reduced after the use of stem cells transplantation against conservative treatment.
The results obtained in the research allowed to propose a procedure of stem cell transplantation for the treatment of left ventricle systolic dysfunction in patients with DCM from cardiac transplant waiting list.
Pages: 384-388  |  441 Views  39 Downloads


The Pharma Innovation Journal
How to cite this article:
Artur Gabriyelyan. Left ventricular 2D speckle tracking echocardiography, quality of life and annual mortality in patients with dilated cardiomyopathy from cardiac transplant waiting list. Pharma Innovation 2018;7(1):384-388.
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