Clinical features of the non-alcohol fat liver disease in advanced age patients with the diabetes mellitus type 2
In a retrospective study, the history of the disease was studied in 143 patients: I group of young age (25-44 years) - 45, II group of middle age (45-60 years) - 60, and III group of the elderly (61-75 years) - 58, patients on NAFLD in combination with type 2 diabetes. The average age of patients in the I group was (40.33 ± 1.02) years; ІІ - (53,09 ± 0,53) years and ІІІ - (64,58 ± 0,66) years. The period of diabetes finding in the 1st group was from 1 to 12 years (on average (6,27 ± 0,93) years, in the second group - (9,38 ± 0,80) years and in the third group - 1 to 53 years, on average (14,61 ± 1,43) years, with age in the dynamics of the NAFLD, the number of cases with fatty infiltration decreases to 60 years, at the same time it increases - with steatohepatitis and dyslipidemia. Arterial pressure tends to increase from the 25th year of life (p<0.05). In patients with middle and advanced age, fluctuations of hyperglycemia became more frequent. The size of the right lobe of the liver (17.0 cm) would be in the largest in case of illness for a period of 1 year in young patients, and the smallest (8.5 cm) in patients in group III.As the age of the number of cases with stage I, fatty hepatosis decreases, and the third stage increases accordingly.In I group of patients, the intensity of the mesenchymal-inflammatory syndrome is minimal.The index of thymol test in patients of middle and advanced age is increasing, besides, women exhibit more pronounced signs of mesenchymal-inflammatory syndrome in groups ІІ and ІІІ, as compared with men. Both in young and in patients of middle and advanced age, the liver is enlarged, in the last oneslittle bit more than in young ones. The level of triglycerides in women with age was significantly lower. In the group of patients over the age of 44 years, there is an increase in the level of very low density lipoprotein, and significant deviations in the lipid profile of the blood, which supports the high risk of atherosclerosis, with a greater tendency in men. The attention of a fairly large number of patients with elevated ESR, which is more often found in women, less frequently - in men.
How to cite this article:
SA Pavlovsky. Clinical features of the non-alcohol fat liver disease in advanced age patients with the diabetes mellitus type 2. Pharma Innovation 2018;7(1):521-524.