Optimization of pharmacological treatment of acute intestinal obstruction
Indices of lipid peroxidation (LPO), middle weight molecules (MWM), and changes in the structure of the liver and the impact of Reamberin solution on them were analyzed in 202 patients with acute small intestinal obstruction (ASIO). Endogenous intoxication indices were established to increase along with the increase in enteral deficiency. In case of ASIO increase in lipid peroxidation products, MWM in serum, and decrease in ceruloplasmin securities, significant changes in the liver (destruction of granular and smooth endoplasmic reticulum, mitochondria, hepatocytes nuclei) were observed. Surgical resolution of ASIO leads to further temporary deterioration of liver structure, increase in MWM, and indices of lipid peroxidation and decrease in ceruloplasmin levels. Prescription of antioxidant therapy in the postoperative period promotes reparative processes in hepatocytes and leads to normalization of endogenous intoxication indices in blood serum and helps reduce postoperative mortality.
How to cite this article:
Vasyl Skrypko. Optimization of pharmacological treatment of acute intestinal obstruction. Pharma Innovation 2018;7(1):451-453.