Synthesis of series of chalcone and pyrazoline derivatives
Swati R Jadhav, Manoj Gayake and Sushma R Katade
Amongst heterocyclic compounds, nitrogen containing five membered heterocycles, Pyrazoline has to be the most useful for biological activities. Pyrazoline refers to the class of simple five member ring organic compounds of the heterocyclic series characterized by a 5-membered ring structure composed of three carbon atoms and two nitrogen atoms in adjacent positions. Being so composed and having pharmacological effects on humans, they are classified as alkaloids, although they are rare in nature. Literature survey shows, pyrazoline derivatives were found to have potential antipyretic-analgesic, tranquillizing, muscle relaxant, psycho analeptic, antiepileptic, antidepressant, anti-inflammatory, insecticidal and antimicrobial and antihypotensive activities. One of the methods for the synthesis of Pyrazoline derivatives is from α, β-unsaturated carbonyls (chalcone) by cyclization with hydrazine and substituted hydrazines. Chalcone are prepared by condensing Aryl ketones with aromatic aldehydes in presence of suitable condensing agents. In this paper we report the synthesis and characterization by 1H-NMR of series of some chalcone and pyrazoline derivatives were synthesised.
How to cite this article:
Swati R Jadhav, Manoj Gayake, Sushma R Katade. Synthesis of series of chalcone and pyrazoline derivatives. Pharma Innovation 2018;7(1):223-225.