A study of newly synthesized via green chemistry approach towards 4-methylsulfanyl-2-oxo-6-(-2-oxo-2-h chromene-3-yl)-2h pyran-3-carbonitrile and their derivatives and antibacterial activities
Santosh G Badne1 and Gajanan W Belsare
3-actyl coumarin was prepared by a well known name reaction Knovengel reaction in basic condition. A mixture of Salicylaldehyde and ethyl acetoacetate was mixed and piperdine was added into that mixture slowly. This mixture was stirred well and kept at freezing temperature for 2-3 hours. A yellow coloured Solid was separates out. In addition to that we have been planned to synthesize a new heterocyclic compound 4-methylsulfanyl-2-oxo-6-(-2-oxo-2-H Chromene-3-yl)-2H pyran-3- Carbonitrile (I) by reaction of 3-acetyl coumarin with ethyl-2-cyano,3,3-bismethyl thioacrylate in prescence of KOH without solvent only by constant grinding at room temperature for 3- 4 Hours. Solid separates out with appreciable yield. Thereafter it has been planned to synthesize 4-substitued derivatives. The parent compound which will show the nucleophillic substitution reaction at 4-position. The derivative was prepared by the reaction of parent Compound (I) and Substituted Anilines, Phenols Nitro Compounds etc.
How to cite this article:
Santosh G Badne1, Gajanan W Belsare. A study of newly synthesized via green chemistry approach towards 4-methylsulfanyl-2-oxo-6-(-2-oxo-2-h chromene-3-yl)-2h pyran-3-carbonitrile and their derivatives and antibacterial activities. Pharma Innovation 2018;7(1):123-127.