Vol. 7, Issue 1 (2018)
Recent approaches in diagnosis and management of canine hypothyroidism: A review
Manu Jaiswal, PC Shukla, Amita Tiwari, Devendra Gupta, Brejesh Singh, Priya Maravi, Anjali Singh, DS Khare, Rakshanda Bhagat and Amir Amin Sheikh
Hypothyroidism is the most frequently diagnosed endocrinopathy in dogs characterised by diminished production of the thyroid hormones i.e. thyroxine (T4) and thyronine (T3) and is of three types: primary hypothyroidism (>95 percent), secondary hypothyroidism and tertiary hypothyroidism. In adult dog, the most consistent clinical signs of hypo-thyroidism are due to decreased cellular metabolism and dermatological manifestations. Additional clinical signs may affect the neuromuscular system, gastrointestinal system and reproductive system. The presence of appropri¬ate clinical signs is imperative, especially when relying on baseline thyroid hormone concentrations for the diagnosis. Identification of mild non-regenerative anaemia on the complete blood count and an increased serum cholesterol concentration on a serum biochem¬istry panel adds further support for hypothyroidism. Low serum T4, free T4 and increased serum TSH concentrations in a dog with appropriate clinical signs and clinic-pathological abnormalities strongly support the diagnosis of hypothyroidism, especially if systemic illness is not present. Initial treatment of choice, regardless of the underlying cause of hypothyroidism is synthetic L-T4 sodium. The recommended initial dose for healthy hypothyroid dog is 0.02 mg/kg PO every 12 hours. The plasma half-life of L-T4 sodium in dogs ranges from 9 to 14 hours and depends on the dos¬age and frequency of administration, with higher dosages and more frequent administration associated with a shorter half-life of L-T4 sodium. With appropriate therapy, all of the clinical signs and clinic-pathological abnormalities associated with hypo-thyroidism should resolve.
How to cite this article:
Manu Jaiswal, PC Shukla, Amita Tiwari, Devendra Gupta, Brejesh Singh, Priya Maravi, Anjali Singh, DS Khare, Rakshanda Bhagat, Amir Amin Sheikh. Recent approaches in diagnosis and management of canine hypothyroidism: A review. Pharma Innovation 2018;7(1):90-94.