Microwave assisted synthesis of novel 3-mercapto-4,5-disubstituted 1,2,4-triazole derivatives and evaluation of antimicrobial, antitubercular activity
Mamta Kadawla, Jyoti sinha and Prabhakar Kumar Verma
A series of 3-Mercapto-4,5-disubstituted 1,2,4-triazole derivatives (T1-T18) has been synthesized under conventional and microwave irradiation and compared the results. The reaction time decreases hours to minutes along with yield enhancement. The structures of these compounds were characterized by means of FT-IR, 1H-NMR, 13C NMR. Representative compounds have been screened for their antimicrobial activity by tube dilution method and antitubercular activity by Micro plate Alamar Blue assay method. Compound T9, T11, T13 and T15 showed excellent antimicrobial activity. Compound T-3, T-9 showed excellent antitubercular activity against MTB H37Rv (MIC 6.25 µg/ml). In the present study classification models have been developed for the prediction of antimicrobial activity of 1,2,4-triazole analogs.
How to cite this article:
Mamta Kadawla, Jyoti sinha, Prabhakar Kumar Verma. Microwave assisted synthesis of novel 3-mercapto-4,5-disubstituted 1,2,4-triazole derivatives and evaluation of antimicrobial, antitubercular activity. Pharma Innovation 2018;7(1):41-47.