Drug utilization studies play crucial role in the health sector and ultimately provides insight into the efficiency of drug use and results of such research can be used to help to set priorities for the rational use of medicines and allocation of health care budgets. Acute Coronary Syndrome (ACS) is an emergency condition where usage of many drugs during its management in the Intensive Care Units is common. This could be a potential cause for Polypharmacy, Drug-Drug Interactions and increased Cost Burden on patients. Keeping in view of this scenario, our study was undertaken to analyze the drug utilization patterns in ACS.
Methods: The study was conducted at Viswabharathi General Hospital, after obtaining permission from the Institutional Ethics Committee. We have collected data of 68 case records of the patients diagnosed with Acute Coronary Syndrome and evaluated for prescribing patterns in consonance with WHO prescribing indicators. The results were analyzed using Descriptive Statistics and T- test.
Results: In this study we analysed total of 68 case records of the patients diagnosed with Acute Coronary Syndrome (ACS) out of that 47 (69.11%) belongs to male patients and 21 (30.88%) were of female patients. The mean age of patient was 57 years; most of the patients belonging to age group of 51-60 years (36.76%). Number of patients undergoing thrombolysis were 30 (44.11%) and 38 (55.88%) underwent percutaneous coronary intervention (PCI). Total 526 drugs were prescribed in 68 patients. Most frequently prescribed drugs were antiplatelet drugs like Clopidogrel and Aspirin, also Statins like Atorvastatin in 100% encounters. Average number of drugs per encounter was 7.73. Percentage of drugs prescribed by Branded name was 89.73%.
Out of total drugs 283 (53.61%) were prescribed from National list of essential medicines 2015 and the Fixed Dose Combinations (FDC) were 22.43%.
Conclusions: The present study provides valuable insight about the overall pattern of drugs used in Acute Coronary syndrome. We observed Polypharmacy and prescription of drugs with Branded names so Physician should be encouraged to prescribe drugs with generic name. Rational prescription is the need of the hour.