Vol. 6, Issue 9 (2017)

Author(s):
Jeevana Latha M, Srikanth MK, Srilatha Ch and Narasimha Reddy Y

Abstract:
The present combination deals with toxico biochemical alteration in broiler chicken produced by experimental administration of ochratoxin A (OA) and citrinin (CTN) combination @ 2 ppm and 25 ppm respectively for a period of six weeks and efficacy of ameliorating agents in reducing the toxic effects. Experimental design consisted of four dietary Group including control (Group-I), toxin (Group-II) and ameliorative Group (Group III and IV). Birds were sacrificed at an interval of 14^th, 28^th and 42^nd days of experiment and whole blood samples were collected for the estimation of biochemical profiles. The serum biochemical profile of the toxic Group of birds showed a significant (P<0.05) increase in certain parameters like uric acid, creatinine, blood urea nitrogen (BUN), glucose, albumin: globulin (A/G) ratio, gamma glutamyl transferase (GGT) activity, alkaline phosphatase (ALP) activity and alanine transaminase (ALT), whereas some other parameters like cholesterol, total proteins, albumins, globulins, calcium and phosphorus were significantly (P<0.05) decreased. However toxins did not showed any significant effect on enzymatic activity of aspartate transaminase (AST). These parameters were moderately ameliorated by activated charcoal and yeast when compared to activated charcoal alone.