Formulation and In vitro evaluation of elvitegravir solid dispersion
K Navaneetha, N Jabili, B Venkateswara Reddy and T Saritha
The present study deals with the formulation and evaluation of elvitegravir solid dispersions to improve the oral bioavailability of poorly water soluble drug. They are usually presented as amorphous products, mainly obtained by two major different methods, for example, fusion and solvent evaporation. Among the different methods of preparation of solid dispersion, fusion method was found to be most effective. FTIR studies were performed to identify the physicochemical interaction between drug and carriers and found to be compatible. Solid dispersion of elvitegravir was prepared with PEG 6000, Urea and Mannitol in different drug: carrier ratio using different methods. The prepared solid dispersions were evaluated for solubility analysis, drug content, In-vitro drug release studies and SEM studies. The formulation FSDPN3 containing PEG 6000 showed highest drug release within 20mins.
How to cite this article:
K Navaneetha, N Jabili, B Venkateswara Reddy, T Saritha. Formulation and In vitro evaluation of elvitegravir solid dispersion. Pharma Innovation 2017;6(9):29-32.