Vol. 6, Issue 8 (2017)

Author(s):
Tekade Bharat W, Jadhao Umesh T, Patil Pooja, Mahajan Sagar and Patil Vijay R

Abstract:
The present research investigation carried out was aimed to develop a Floating tablet of Anticancer Drug Capecitabine. Floating Tablet was formulated using HPMC K15M, Carbomer 934, Sodium Alginate, Sodium Bicarbonate, and Citric Acid which is prepared by wet granulation technique. The prepared Tablet was evaluated for physical parameter, Swelling index, buoyancy Lag Time and in vitro drug release. Based on the % drug release, swelling index, floating lag time and floating time, formulation C2 was an optimized formulation. Formulation C2 showed 91.77% drug release at the end of 24 h. Floating lag time was found to be 38 sec. These tablets showed matrix integrity for more than 24h. Formulations which have higher swelling index shows sustained release of drug in formulation. FTIR Studies shows there was no interaction found between any excipient and drug.