Synthesis, characterization and biological screening of novel 1, 4-dihydropyridine derivatives for certain pharmacological activities
Mathew George, Lincy Joseph and Chippy Joseph
A series of 1, 4-dihydropyridine derivatives were prepared from three compounds by the condensation reaction of ethyl acetoacetate, aromatic aldehyde and ammonium acetate at 700C. Derivatives of 1, 4-dihydropyridines are one of the most potent calcium antagonists. The compound exhibits various pharmacological actions which include calcium channel antagonist property, antihy pertensive  anti-inflammatory, antifungal, analgesic, antimicrobial, antithrombotic actions. It also shows vasodialation, anticonvulsant and stress protective effect by binding to L and N channels .
How to cite this article:
Mathew George, Lincy Joseph, Chippy Joseph. Synthesis, characterization and biological screening of novel 1, 4-dihydropyridine derivatives for certain pharmacological activities. Pharma Innovation 2017;6(8):165-170.