Vol. 6, Issue 8 (2017)

Author(s):
Mathew George, Lincy Joseph and Chippy Joseph

Abstract:

A series of 1, 4-dihydropyridine derivatives were prepared from three compounds by the condensation reaction of ethyl acetoacetate, aromatic aldehyde and ammonium acetate at 70⁰C. Derivatives of 1, 4-dihydropyridines are one of the most potent calcium antagonists. The compound exhibits various pharmacological actions which include calcium channel antagonist property, antihy pertensive ^[1] anti-inflammatory, antifungal, analgesic, antimicrobial, antithrombotic actions. It also shows vasodialation, anticonvulsant and stress protective effect by binding to L and N channels ^[2].