Vol. 6, Issue 8 (2017)

Author(s):
Chintu kotadiya, UD Patel, CM Modi, HB Patel, VA Kalaria and VB Chauhan

Abstract:
The study was carried out to evaluate effect of Opuntia elatior fruit juice and quercetin administration on alteration of glucose level, lipid profile, hyperalgesic response and spontaneous motor activity in diabetic rats. Administration of Opuntia elatior and quercetin for 28 days has significantly lowered blood glucose level in diabetic rats. Upon glucose tolerance test, the glucose levels in rats of different treatment groups were significantly increased at 30 and 60 minutes after oral glucose load. However, glucose levels of diabetic rats treated with Opuntia elatior fruit juice and quercetin alone and in combination or Glibenclamide were significantly lowered at the end of 120 min. In lipid profile, levels of total cholesterol and triglyceride were significantly increased while levels of HDL-cholesterol and LDL-cholesterol were non-significantly higher in diabetic control group compared to other groups. The values of altered lipid profile were changed towards normal levels when rats treated with Opuntia elatior fruit juice along with quercetin. Treatment with glibenclamide, Opuntia elatior fruit juice and quercetin alone and in combination attenuated the hyperalgesic response in diabetic rats. There was significant reduction in locomotor activity of diabetic control rats compare to normal controls which was improved with treatment of Opuntia elatior fruit juice and quercetin alone and in combination. Opuntia elatior fruit juice and quercetin treatment has glucose lowering effect along with improvement in altered lipid profile and other pathophysiological alterations in diabetic rats.