To formulate and evaluate taste masked chewable tablet of Levocetirizine dihydrochloride and Montelukast sodium using ion exchange resin as a drug carrier
Rahul Gupta, Gulshan Chhabra, Dr. Kamla Pathak, Harish Kr Bishnoi And Anil Kuma
The aim of this research was to mask the bitter taste of Levocetirizine dihydrochloride & Montelukast sodium using ion exchange resin and to formulate a taste masked chewable tablet formulation with better patient compliance.Tulsion-335 & kyron T-114 containing crosslinked polyacrylic backbone were used as taste masking agents. The drug resin complex was prepared by complexation of drug with resin using batch processes taking different drug: resin ratio 1:1, 1:2, 1:3 respectively. The optimum drug resin ratio & time required for maximum complexation was optimized. The drug resinate was evaluated for assay (% drug content), % drug release, micromeritics properties, SEM, DSC, DRS & taste characterstics of the formulation. SEM photomicrograph of drug resin complex revealed that entrapment of drug has been achieved. DSC thermogram revealed that there is change in melting point of levocetrizine and montelukast and sharp peaks changes into broad peaks in drugs resin complex. DRS shows disappearance of stretching vibration of amine functional group at 3323 and 3407 cm-1 in Levocetirizine dihydrochloride and Montelukast sodium respectively and appearance of new stretching vibration of amide group at 3409 cm-1 in drug resin complex confirming the formation of amide linkage. The taste perception has been achieved by amide formation. Further SEM, DSC & DRS study confirmed the monomolecularity of entrapped drug in the ion exchange resin beads. The taste evaluation depicted the successful taste masking of drug: resin complexes. Chewable tablets were developed from drug: Tulsion-335 in optimum ratio of 1:1, 1:2 & 1:3. The formulations were evaluated for the uniformity of dispersion, disintegration time & in vitro drug release. The maximum drug release was found to be 98.25% of Levocetirizine dihydrochloride & 98.55% of Montelukast sodium in 60 minutes for F3 formulation. Thus, Complexation with ion exchange resin is a simple and efficient technique of masking the bitter taste.
How to cite this article:
Rahul Gupta, Gulshan Chhabra, Dr. Kamla Pathak, Harish Kr Bishnoi And Anil Kuma. To formulate and evaluate taste masked chewable tablet of Levocetirizine dihydrochloride and Montelukast sodium using ion exchange resin as a drug carrier. Pharma Innovation 2017;6(7):27-32.