Pharmacology and impact of tretinoin on the treatment of premalignant squamous lesions of the oral cavity
Dr. Abhishek Deswal And Dr. Hardeep Dhanda
Retinoids are the natural and synthetic derivatives of vitamin A. Natural and synthetic derivatives of vitamin A i.e. retinoids signal potent differentiation and growth-suppressive effects in diverse normal, premalignant, and malignant cells. Retinoids have been studied as chemoprevention for tumor, anti-angiogenic and anti-inflammatory agents. Vitamin A derivatives i.e. tretinoin modulates growth and differentiation of cells, and its deficiency enhances susceptibility to carcinogenesis. In this review chemopreventive mechanism of action (pharmacology) of vitamin A is discussed, and a review of impact of Tretinoin on the treatment of premalignant squamous lesion for oral cavity by using vitamin A derivative is included. Basically when we study its mechanism of action is unknown, but retinoids on epithelial differentiation and proliferation led to investigate the efficacy of retinoids in reversing oral leukoplakia. The objective of the current report was to review the possible role of vitamin A derivatives in the management of patients with oral lesions with a risk of transformation to carcinoma. Although administration of higher concentrations of retinoic acid results in suppression of oral leukoplakias only, its use in the treatment of patients with recurrent and persistent lesions may be justified for controlling lesions that otherwise may progress. In this regard, the vitamins derivative i.e. Tretinoin are useful pharmacological tools to reveal important pathways targeted in chemoprevention and further controlled clinical studies are needed.
How to cite this article:
Dr. Abhishek Deswal And Dr. Hardeep Dhanda. Pharmacology and impact of tretinoin on the treatment of premalignant squamous lesions of the oral cavity. Pharma Innovation 2017;6(7):20-26.