GLN27GLU polymorphism β2-adrenergic receptor gene and the risk of arterial hypertension in patients with bronchial asthma
Liudmyla N Prystupa, Anna N Bondarkova, Ninel A Murenets, Vladyslava V Kmyta and Nataliia G Kuchma
Arterial hypertension (AH) and bronchial asthma (BA) have common genetic factors, particularly polymorphism in the β2-adrenergic receptor gene (ADRB2). Substitution at the coding element Gln27Glu is best investigated; it can lead to abnormal activity regulation of the receptor. The aim of our research was to study AH in BA patients in Ukrainian population with regard to Gln27Glu polymorphism in the ADRB2 gene and body mass. Examined patients were divided into 2 groups: group I included 52 patients with BA without AH; group II comprised 143 patients with BA accompanied by AH. Gln27Glu (rs1042714) polymorphism in the ADRB2 gene was detected using polymerase chain reaction. Statistical analysis was performed using SPSS–21 program. P-value <0.05 was considered significant. With no regard to body mass, no correlation was found between AH risk (р = 0.69), systolic and diastolic AP (р1 = 0.142 and р2 = 0.073) and Gln27Glu polymorphism in the ADRB2 gene in BA patients. Still, AH risk evaluation in BA patients with regard to BMI demonstrated that the minor allele homozygotes of Glu27Glu genotype had 2.93 times higher risk of AH development as compared to Gln27Gln genotype carriers. At the same time, obesity was observed in 81.3% of BA patients with AH who were the carriers of Glu27Glu genotype of Gln27Glu polymorphism in the ADRB2 gene.
How to cite this article:
Liudmyla N Prystupa, Anna N Bondarkova, Ninel A Murenets, Vladyslava V Kmyta, Nataliia G Kuchma. GLN27GLU polymorphism β2-adrenergic receptor gene and the risk of arterial hypertension in patients with bronchial asthma. Pharma Innovation 2017;6(4):103-106.